Production of high-yield and high-quality fruits is always the long-term objective of fruit crop cultivation, which, however, is challenged by various abiotic stresses such as drought, extreme temperatures and high salinity, and the adverse impacts of abiotic stresses on fruit crops are exacerbated by climate change in recent years. To cope with these environmental stressors, fruit crops have evolved adaptative strategies involving physiological changes and molecular regulation. In this review, we summarise the relevent changes in photosynthesis, osmotic and reactive oxygen species (ROS) equilibrium, metabolism and protein homeostasis in response to abiotic stresses. Moreover, perception of environmental stimuli as well as recent progress of underlying regulatory mechanisms is also discussed. Based on our current knowledge, possible strategies for stress resilience improvement in fruit crops are accordingly proposed. In addition, we also discuss the challenges in identification of key nodes in plant responses to multiple stresses and development of stress-resilient fruit crops, and addressing these issues in the future would advance our understanding of how fruit crops combat abiotic stresses and facilitate the breeding of superior fruit crops that can adapt to and thrive in the changing environments.