Stomatal pores serve as primary entry points for pathogen invasion. Stomatal closure is a crucial strategy that plants employ to counter pathogen attack. Here, we report that F‐BOX STRESS‐INDUCED (FBS) is essential for modulating stomatal closure, thereby enhancing resistance to bacteria in Arabidopsis thaliana. The fbs2-1 fbs3-1 fbs4-2 triple mutant displayed increased susceptibility to Pseudomonas syringae pv. tomato (PstDC3000) due to impaired stomatal closure. Additionally, FBS4 interacts with and degrades the basic helix-loop-helix (bHLH) transcription factor FAMA. Both the fama-1 single mutant plants and the fama-1 fbs2-1 fbs3-1 fbs4-2 quadruple mutant plants exhibited resistance to PstDC3000 inoculation. Furthermore, the expression levels of abscisic acid (ABA)-responsive genes RD29A, RD29B, ABI2, and CIPK25 were altered in the fbs2-1 fbs3-1 fbs4-2 and fama-1 mutant plants. Collectively, our data demonstrate that FBS, in association with FAMA, plays an important role in pathogen invasion by influencing ABA signaling-related stomatal closure.