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Crystal structure of Arabidopsis deg2 protein reveals an internal PDZ ligand locking the hexameric resting state

作　　者：Renhua Sun, Haitian Fan, Feng Gao, Yajing Lin, Lixin Zhang, Weimin Gong, Lin Liu
影响因子：4.773
刊物名称：THE JOURNAL OF BIOLOGICAL CHEMISTRY
出版年份：2012
卷：287  期：4  页码：37564-37569

论文摘要：

Background: The PDZ protease Deg2 is involved in chloroplast protein quality control through a yet unknown molecular mechanism.
Results: A novel PDZ domain with an internal ligand mediates hexamer formation and locks Deg2 into the resting state.
Conclusion: Formation of the resting hexamer may be a common strategy in a Deg protease subfamily.
Significance: We provide structural insights into the PDZ domain-mediated regulation of Deg proteases.
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